In case you haven’t heard, there was a horrific medical accident in England. Eight gentlemen were taking part in the first human trials of an experimental drug known as TGN1412, which is an anti-inflammatory steroid.
It worked okay in animal tests, but when it was given to humans, disaster resulted. Of the eight gentlement in the test, two received placebos, but the other six collapsed and two of them have major organ failure.
EXCERPTS:
A volunteer taking part in the trial who was given a placebo and therefore escaped the effects described the appalling scene on the ward.
Raste Khan, 23, a television technician, said: "The test ward turned into hell minutes after we were injected. The men went down like dominoes.
"First they began tearing their shirts off complaining of fever, then some screamed out that their heads felt like they were going to explode.
"After that they started fainting, vomiting and writhing around in their beds.
"It was terrifying because I kept expecting it to happen to me at any moment. But I felt fine and I didn’t know why."
Six volunteers suffered catastrophic reactions to trials of the new drug, TGN1412, at Northwick Park Hospital in Harrow, North-West London.
They were the first people in the world to test the drug, being developed by the German pharmaceutical firm, TeGenero, and designed to treat chronic inflammatory conditions and leukaemia. They were paid £2,000 each.
Four are in a serious condition but showing signs of improvement. Two remain critical.
More from The Sun:
"It was terrifying because I kept expecting it to happen to me at any moment. But I felt fine and didn’t know why."
"An Asian guy next to me started screaming and his breathing went haywire as though he was having a terrible panic attack.
"They put an oxygen mask on him but he kept tearing it off, shouting ‘Doctor, doctor, please help me!’ He started convulsing, shouting that he was getting shooting pains in his back"
More from Wikipedia:
Phase I clinical trials conducted by PAREXEL at Northwick Park Hospital, London, hospitalised 6 volunteers in March 2006, with at least 2 of them suffering major organ failure.
After the drug was administered to the last participant, the first participant started complaining of a severe headache, fever and pain and collapsed shortly after. Within a few hours, the remaining participants who received the actual drug had become ill as well, vomiting and complaining of severe pain. Within 12 hours all 6 had collapsed. At least one participant begged the doctors to "put him to sleep" because of the suffering.
Some of the men are reported to have experienced severe swelling with comparisons being made to The Elephant Man. According to doctors, this is caused by the large amount of fluids given as part of the treatment. The patients are being treated with anti-inflammatory steroids. Two of the men were reported to be in a critical condition with the remaining four being in a serious, but improving condition.
TeGenero has apologized to the families involved and insist that these effects were completely unexpected and that all protocols have been followed. An investigation of the case by authorities has now been commenced to find out if the reaction seen is due to a contamination of the drug given, a wrong dose being administered or if it is an inherent flaw in the drug. Criticism has been raised that 6 participants were given the drug in such a short time, which is against the recommendations of some standard literature.
The mention in the Wikipedia entery that police are investigating whether there is "contamination" in the drug given includes the possibility that there was deliberate tampering with the drug, which press accounts indicate the police are looking into.
The options here seem to be: (1) the drug is just harmful to humans where it isn’t to the animals used in trials, (2) accidental overdose, (2) deliberate overdose [highly unlikely], (3) accidental contamination, and (4) deliberate contamination.
The two with major organ failure are not likely to survive. Doctors are trying to flush the drug out of their systems, which produces the massive "Elephant Man"-like swelling that family members have reported.
Any way you go, let’s pray for these guys.

